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论文专利

30. Xia, Y.; Wu, K.; Liu, C.; Zhao, X.; Wang, J.; Cao, J.; Chen, Z.; Fang, M.; Yu, J.; Zhu, C.; Zhang, X.*; Wang, Z*. Filamentous-Actin-Mimicking Nanoplatform for Enhanced Cytosolic Protein Delivery. 2024, 11, (10), 2305600.

29.Xianghan Zhang, Jingkai Gao, Yingdi Tang, Jie Yu, Si Si Liew, Chaoqiang Qiao, Yutian Cao, Guohuan Liu, Hongyu Fan, Yuqiong Xia, Jie Tian*, Kanyi Pu* and Zhongliang Wang*. Bioorthogonally Activatable Cyanine Dye with Torsion-Induced Disaggregation for In Vivo Tumor Imaging. Nature Communications, 2022, 13 (1), 3513. (IF: 17.694)

28. Yang, Y.; Fan, Z.; Dong, Q.; Sun, W.*; Zhang, X.*; Guan, L.; Wang, L*. Sustainable Approach to Methine-Substituted Heptamethine Cyanines from Bioderived Furfural and Their Phototherapy Potential. 2022, 10, (7), 2282-2288.

27. Xianghan Zhang, Sumei Zhao, Zhiqing Gao, Jialin Zhou, Yuqiong Xia, Jie Tian*, Changhong Shi*, Zhongliang Wang*. Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo. Nano Research, 2021, 14 (7), 2432-2440. (IF: 10.269)

26. Yang, Y.; Fan, Z.; Dong, Q.; Sun, W.*; Zhang, X.*; Guan, L.; Wang, L.*, Sustainable Approach to Methine-Substituted Heptamethine Cyanines from Bioderived Furfural and Their Phototherapy Potential. ACS Sustainable Chemistry & Engineering 2022, 10 (7), 2282-2288.

25. Xia, Y.*; Wu, Y.; Cao, J.; Wang, J.; Chen, Z.; Li, C.; Zhang, X.*, Liposomal Glucose Oxidase for Enhanced Photothermal Therapy and Photodynamic Therapy against Breast Tumors. ACS biomaterials science & engineering 2022, 8 (5), 1892-1906. 

24. Xia, Y.*; Xu, C.; Wu, K.; Wang, J.; Cui, C.; Wu, Y.; Li, C.; Zhang, X.*, Self-quenched liposomal probes for tumor imaging based on cellular on/off system. Materials Today Communications 2022, 30, 103207.

23. Zhang, X.; Gao, Z.; Xia, Y.; Dong, Q.; Cao, Y.; Jia, Q.; Sun, F.; Li, Z.; Tang, C.; Yu, J.*, Insight into the spatial interaction of D-pi-A bridge derived cyanines and nitroreductase for fluorescent cancer hypoxia detection. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2022, 273, 121031.

22. Zhang, X.; Gao, X.; Zhou, J.; Gao, Z.; Tang, Y.; Tian, Z.; Ning, P.; Xia, Y., Albumin-based fluorescence resonance energy transfer nanoprobes for multileveled tumor tissue imaging and dye release imaging. Colloids and Surfaces B: Biointerfaces 2021, 199, 111537.

21. Jin, X.; Gao, J.; Wang, T.; Feng, W.; Li, R.; Xie, P.; Si, L.; Zhou, H.*; Zhang, X.*, Rhodol-based fluorescent probes for the detection of fluoride ion and its application in water, tea and live animal imaging. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2020, 224, 117467.

20. Xia, Y.; Xu, C.; Zhang, X.; Gao, J.; Wu, Y.; Li, C.; Wang, Z., An activatable liposomal fluorescence probe based on fluorescence resonance energy transfer and aggregation induced emission effect for sensitive tumor imaging. Colloids and surfaces. B, Biointerfaces 2020, 188, 110789.

19. Xia, Y.; Xu, C.; Zhang, X.; Ning, P.; Wang, Z.*; Tian, J.*; Chen, X.*, Liposome-based probes for molecular imaging: from basic research to bedside. Nanoscale 2019, 11, 5822-5838.

18. Hong, F.; Tang, C.; Xue, Q.; Zhao, L.; Shi, H.;* Hu, B.;* Zhang, X.*, Simultaneously Enhanced Singlet Oxygen and Fluorescence Production of Nanoplatform by Surface Plasmon Resonance Coupling for Biomedical Applications. Langmuir  2019, 35 (46), 14833-14839.

17. Jin, X.; Zhao, S.; Wang, T.; Si, L.; Liu, Y.; Zhao, C.; Zhou, H*.; Leng, X.; Zhang, X.*, Near-infrared fluorescent probe for selective detection of H2S and its application in living animals. Analytical and Bioanalytical Chemistry 2019, 411 (23), 5985-5992.

16. Xianghan Zhang, Bo Wang, Yuqiong Xia, Sumei Zhao, Zuhong Tian, Pengbo Ning, Zhongliang Wang*. In vivo and in situ activated aggregation-induced emission probes for sensitive tumor imaging using tetraphenylethene-functionalized trimethincyanines-encapsulated liposomes. ACS Applied Materials & Interfaces 2018, 10(30):25146-25153.

15. Xianghan Zhang, Bo Wang, Na Zhao, Zuhong Tian, Yunpeng Dai, Yongzhan Nie, Jie Tian, Zhongliang Wang, Xiaoyuan Chen. Improved tumor targeting and longer retention time of NIR fluorescent probes using bioorthogonal chemistry. Theranostics, 2017, 7(15) : 3794-3802.

14. Xilang Jin, Xianglong Wu, Bo Wang, Pu Xie, Yaolong He, Hongwei Zhou, Bo Yan, Jingjing Yang, Weixing Chen, Xianghan Zhang*. A reversible fluorescent probe for Zn2+ and ATP in living cells and in vivo。Sensors & Actuators: B. Chemical , 2018, 261, 127-134.

13.  Lv, R.; Yang, F.; Jiang, X.; Hu, B.; Zhang, X.; Chen, X.; Tian, J. Plasmonic modulated upconversion fluorescence by adjustable distributed gold nanoparticles. Journal of Luminescence 2020, 220, 116974.

12. Hong, F.; Tang, C.; Xue, Q.; Zhao, L.; Shi, H.; Hu, B.*; Zhang, X*. Simultaneously Enhanced Singlet Oxygen and Fluorescence Production of Nanoplatform by Surface Plasmon Resonance Coupling for Biomedical Applications. Langmuir 2019, 35 (46), 14833-14839.

11. Ning, P.; Wu, Z.; Li, X.; Zhou, Y.; Hu, A.; Gong, X.; He, J.; Xia, Y.; Guo, K.; Zhang, R.; Zhang, X.; Wang, Z. Development of functionalized gold nanoparticles as nanoflare probes for rapid detection of classical swine fever virus. Colloids Surf B Biointerfaces 2018, 171, 110-114.

10. Xilang Jin, Jingkai Gao, Pu Xie, Mengchen Yu, TingWang, Hongwei Zhou, Aijie Ma, QianWang, Xin Leng, Xianghan Zhang*. Dual-functional probe based on rhodamine for sequential Cu2+ and ATP detection in vivo. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 204, 657-664.

9. Zhang, X.; Zhao, N.; Wang, B.; Tian, Z.; Dai, Y.; Ning, P.; Chen, D. Structure-inherent near-infrared fluorescent probe mediates apoptosis imaging and targeted drug delivery in vivo. Dyes and Pigments 2017, 138, 204-212.

8. Ning, P.; Gao, L.; Zhou, Y.; Hu, C.; Lin, Z.; Gong, C.; Guo, K.; Zhang, X. Caveolin-1-mediated endocytic pathway is involved in classical swine fever virus Shimen infection of porcine alveolar macrophages. Veterinary microbiology 2016, 195, 81-86.

7. Guan, L.; Li, A.; Song, Y.; Yan, M.; Gao, D.; Zhang, X.; Li, B.; Wang, L. Nonplanar Monocyanines: Meso-Substituted Thiazole Orange with High Photostability and Their Synthetic Strategy as well as a Cell Association Study. The Journal of Organic Chemistry 2016, 81 (15), 6303-6313.

6. Gao, D.; Li, A.; Guan, L.; Zhang, X.; Wang, L. Y. Solvent-dependent ratiometric fluorescent merocyanine dyes: Spectral properties, interaction with BSA as well as biological applications. Dyes and Pigments 2016, 129, 163-173.

5. Dai, Y.; Yin, J.; Huang, Y.; Chen, X.; Wang, G.; Liu, Y.; Zhang, X.; Nie, Y.; Wu, K.; Liang, J. In vivo quantifying molecular specificity of Cy5.5-labeled cyclic 9-mer peptide probe with dynamic fluorescence imaging. Biomedical Optics Express 2016, 7 (4), 1149-1159.

4. Zhang, X. H.; Liu, Q.; Shi, H. J.; Wang, L. Y.; Fu, Y. L.; Wei, X. C.; Yang, L. F. Synthesis, spectral properties of cell-permeant dimethine cyanine dyes and their application as fluorescent probes in living cell imaging and flow cytometry. Dyes and Pigments 2014, 100, 232-240.

3. Xia, Y.; Qi, S.; Zhang, X.; Li, L.; Qu, X.; Zhang, X.; Liang, J. Construction of Thermal- and Light-Responsive Liposomes Noncovalently Decorated with Gold Nanoparticles. RSC Advances 2014, 4, (84), 44568-44574.

2. Xin, J.; Zhang, X.; Liang, J.; Xia, L.; Yin, J.; Nie, Y.; Wu, K.; Tian, J. In Vivo Gastric Cancer Targeting and Imaging Using Novel Symmetric Cyanine Dye-Conjugated Gx1 Peptide Probes. Bioconjugate Chemistry  2013, 24, (7), 1134-1143.

1. Chen, D.; Zhu, S.; Yi, H.; Zhang, X.; Chen, D.; Liang, J.; Tian, J. Cone Beam X-Ray Luminescence Computed Tomography: A Feasibility Study. Medical Physics 2013, 40, (3), 031111.

授权专利:

6. 张象涵,高靖凯,王忠良,夏玉琼,宁蓬勃,张瑞丽。基于点击激活大空间位阻抗聚集淬灭七甲川功能型花菁染料及其制备方法和应用。申请号ZL 201910817202.8

5. 夏玉琼,许春仲,张象涵,王忠良,张瑞丽,吴延坤,李彩儒。一种开关型脂质体纳米荧光探针及其制备方法和用途,ZL 201910590952.6

4. 宁蓬勃,王忠良,龚小程,姚慧敏,刘敏,龚春梅,夏玉琼,张象涵,贾茜。一种基于功能化巨噬细胞/单核细胞的靶向递送系统及其构建与应用,CN202010033464.8

3. 王忠良,乔晁强,张瑞丽,王永东,张象涵,田捷。基于脂质体膜的金属有机骨架材料的表面功能化修饰方法,CN201710386696.X

2. 张象涵,曾琦,陈丹,夏玉琼,宋红瑾,刘亚军,王博,沈超,詹勇华,梁继民,田捷。一种制备共轭桥链中位取代花菁染料的方法, ZL201410126346.6

1. 张象涵,辛静,梁继民,田捷,詹勇华,陈丹,王福,屈晓超。对称五甲川菁染料及其在分子影像中的应用,专利号ZL201210436931.7