The current research accomplishments: 76 peer-reviewed journal publications, including 50 first and corresponding author publications, and 2 book chapters.

Book chapters

1. Xueli Chen, Dongmei Chen, Fenglin Liu, Wenxiang Cong, Ge Wang, and Jimin Liang*. Optical-CT Imaging (Chapter 11), Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications (Editors: George C. Kagadis, Nancy L. Ford, Dimitrios Karnabatidis, and George K. Loudos), Taylors & Francis Inc, 11/03/2016
2. Jie Tian, Jimin Liang, Xueli Chen, and Xiaochao Qu. Molecular Optical Simulation Environment (Chapter 2), Molecular Imaging: Fundamentals and Applications (Editor: Jie Tian), Zhejiang University Press and Springer-Verlag, 15-46, 2012.

First & Corresponding author peer-reviewed papers

1. Xueli Chen^#,*, Xinyu Wang^#, Lin Wang^#, Peng Lin, Yonghua Zhan, and Ji-Xin Cheng, “Stimulated Raman scattering signal generation in scattering medium using self-reconstructing Bessel beams,” Photonics Research 2020, in press.
2. Xueli Chen^#,*, Shouping Zhu^#, Huiyuan Wang, Cuiping Bao, Defu Yang, Chi Zhang, Peng Lin, Ji-Xin Cheng, Yonghua Zhan, Jimin Liang, and Jie Tian, “Accelerated stimulated Raman projection tomography by sparse reconstruction from sparse-view data,” IEEE Transactions on Biomedical Engineering 2020. DOI: 10.1109/TBME.2019.2935301
3. Yunpeng Dai^#, Duofang Chen^#, Guodong Wang, Jipeng Yin, Yonghua Zhan*, Kaichun Wu, Jimin Liang, and Xueli Chen*, “Kinetic modeling and analysis of dynamic bioluminescence imaging of substrates administered by intraperitoneal injection,” Quantitative Imaging in Medicine and Surgery 2020, in press. DOI: 10.21037/qims.2020.01.01
4. Duofang Chen, Shouping Zhu, Yi Huang, Jimin Liang, and Xueli Chen*, “Removal of random-valued impulse noise from Cerenkov luminescence images,” Medical & Biological Engineering & Computing 2020. DOI: 10.1007/s11517-019-02069-9. Nov. 21, 2019
5. Yunpeng Dai^#, Guodong Wang^#, Duofang Chen, Jipeng Yin, Yonghua Zhan, Yongzhan Nie, Kaichun Wu, Jimin Liang*, and Xueli Chen*, “Intravenous administration-oriented pharmacokinetic model for dynamic bioluminescence imaging,” IEEE Transactions on Biomedical Engineering 2019, 66(3), 843-847. DOI: 10.1109/TBME.2018.2858774 Mar. 2019
6. Ke Li^#, Wenhua Zhan^#, Yulong Chen, Rajiv Kumar Jha*, and Xueli Chen*, “Docetaxel and doxorubicin codelivery by nanocarriers for synergistic treatment of prostate cancer,” Frontiers in Pharmacology 2019, 10, 1436. DOI: 10.3389/fphar.2019.01436
7. Tianyu Yan^#, Qi Zeng^#, Lin Wang, Nan Wang, Honghao Cao, Xinyi Xu, and Xueli Chen*, “Harnessing the power of optical microscopic and macroscopic imaging for natural products as cancer therapeutics,” Frontiers in Pharmacology 2019, 10, 1438. DOI: 10.3389/fphar.2019.01438
8. Nan Wang^#, Honghao Cao^#, Lin Wang, Feng Ren, Qi Zeng, Xinyi Xu, Jimin Liang, Yonghua Zhan, and Xueli Chen*, “Recent advances in spontaneous Raman spectroscopic imaging: instrumentation and applications,” Current Medicinal Chemistry 2019, 26, 1-19. DOI: 10.2174/0929867326666190619114431
9. Hui Xie^#, Huiyuan Wang^#, Lin Wang, Nan Wang, Jimin Liang, Yonghua Zhan, and Xueli Chen*, “Comparative studies of total-variation-regularized sparse reconstruction algorithms in projection tomography,” AIP Advances 2019, 9, 085122. Aug. 23, 2019. DOI: 10.1063/1.5116246
10. Lin Wang, Honghao Cao, Xin Cao, Shenghan Ren, Ke Li, Yonghua Zhan, Xueli Chen*, and Xiaowei He*, “Adaptively hybrid 3rd simplified spherical harmonics with diffusion equation based multispectral Cerenkov luminescence tomography,” IEEE Access 2019, 7, 160779. DOI: 10.1109/ACCESS.2019.2950265
11. Nan Wang^#, Duofang Chen^#, Dan Chen, Cuiping Bao, Jimin Liang, Xueli Chen*, and Shouping Zhu*, “Feasibility study of limited-angle reconstruction for in vivo optical projection tomography based on novel sample fixation,” IEEE Access 2019, 7(1), 87681-87691. DOI: 10.1109/ACCESS.2019.2925096
12. Xinyi Xu^#, Hanrui Li^#, Ke Li, Qi Zeng, Yin Liu, Yun Zeng, Dan Chen, Jimin Liang, Xueli Chen*, and Yonghua Zhan*, “A photo-triggered conjugation approach for attaching RGD ligands to biodegradable mesoporous silica nanoparticles for the tumor fluorescent imaging,” Nanomedicine: Nanotechnology, Biology, and Medicine 2019, 19, 136-144. June 2019
13. Yunpeng Dai^#, Xueli Chen^#,*, Jipeng Yin^#, Guodong Wang, Bo Wang, Yonghua Zhan*, Yongzhan Nie, Kaichun Wu, and Jimin Liang*, “Investigation of the influence of sampling schemes on quantitative dynamic fluorescence imaging,” Biomedical Optics Express 2018, 9(4), 1859-1870. Mar. 26, 2018.
14. Defu Yang, Lin Wang, Dongmei Chen, Chenggang Yan, Xiaowei He, Jimin Liang, and Xueli Chen*, “Filtered maximum likelihood expectation maximization based global reconstruction for bioluminescence tomography,” Medical & Biological Engineering & Computing 2018, 56, 2067-2081. (2nd affiliation) Oct. 2018
15. Lin Wang, Shenghan Ren, and Xueli Chen*, “Comparative evaluations of the Monte Carlo-based light propagation simulation packages for optical imaging,” Journal of Innovative Optical Health Sciences 2018, 11(1), 1750017. DOI: 10.1142/S1793545817500171 (2nd affiliation) Nov. 2017
16. Yun Zeng^#, Jingwen Ma^#, Yonghua Zhan, Xinyi Xu, Qi Zeng, Jimin Liang*, and Xueli Chen*, “Hypoxia-activated prodrugs and redox-responsive nanocarriers,” International Journal of Nanomedicine 2018, 13, 6551-6574. Oct. 2018
17. Defu Yang, Chenggang Yan*, Lei Yang, Dongliang Peng, and Xueli Chen*, “An alternative reconstruction framework with optimal permission source region for bioluminescence tomography,” Optics Communications 2018, 427(11), 112-122. (2nd affiliation) June 2018
18. Lin Wang^#, Xin Cao^#,*, Xu Cao, Fei Kang, Yonghua Zhan, Xiaowei He, Jing Wang*, and Xueli Chen*, “Feasibility study of radioluminescence film imaging: an optical way to detect medical radionuclides,” Optoelectronics and Advanced Materials-Rapid Communications 2018, 12(9-10), 542-546. (2nd affiliation) Sep.-Oct. 2018
19. Hanrui Li^#, Ke Li^#, Yunpeng Dai, Xinyi Xu, Xu Cao, Qi Zeng, Huyulong He, Liaojun Pang, Jimin Liang, Xueli Chen*, and Yonghua Zhan*, “In vivo near infrared fluorescence imaging and dynamic quantification of pancreatic metastatic tumors using folic acid conjugated biodegradable mesoporous silica nanoparticles,” Nanomedicine: Nanotechnology, Biology, and Medicine 2018, 14(6), 1867-1877. Jul. 2018
20. Lin Wang, Xin Cao, Qingyun Ren, Xueli Chen*, Xiaowei He*, “Hybrid model based unified scheme for endoscopic Cerenkov and radio-luminescence tomography: simulation demonstration,” Journal of Applied Physics 2018, 123(18), 184701. (2nd aff.) May 2018
21. Xueli Chen^#, Chi Zhang^#, Peng Lin, Kai-Chih Huang, Jimin Liang, Jie Tian, and Ji-Xin Cheng*, “Volumetric chemical imaging by stimulated Raman projection microscopy and tomography,” Nature Communications 2017, 8, 15117.Apr. 24, 2017. DOI: 10.1038/ncomms15117
22. Yonghua Zhan^#, Wenhua Zhan^#, Hanrui Li, Xinyi Xu, Xu Cao, Shouping Zhu, Jimin Liang, and Xueli Chen*, “In vivo dual-modality fluorescence and magnetic resonance imaging-guided lymph node mapping with good biocompatibility manganese oxide nanoparticles,” Molecules 2017, 22(12), 2208. Dec. 2017.
23. Defu Yang, Xueli Chen*, Chunhui Zhang, Lu Wang, Fanzhen Meng, Qingguo Xie, and Jimin Liang, “Cerenkov luminescence imaging guided selective-reconstruction for a flexible dual-head PET,” Journal of Instrumentation 2017, 12(4), P04005. Apr. 2017
24. Lin Wang^#, Yonghua Zhan^#, Defu Yang, and Xueli Chen*, “Specific modeling of light propagation in live body with coupled SP3-radiosity-diffusion equation,” Journal of Medical Imaging and Health Informatics 2017, 7(4), 820-832. Aug. 2017
25. Xin Cao^#, Yonghua Zhan^#, Xu Cao, Jimin Liang, and Xueli Chen*, “Harnessing the power of Cerenkov luminescence imaging for gastroenterology: Cerenkov luminescence endoscopy,” Current Medical Imaging Reviews 2017, 13(1), 50-57. Apr. 2017
26. Yonghua Zhan^#, Xu Cao^#, Xin Cao, Yingchao Li, Jie Tian, Jimin Liang*, and Xueli Chen*, “Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo,” Journal of Biomedical Nanotechnology 2017, 13(2), 144-154. Apr. 2017. DOI: 10.1166/jbn.2016.2332
27. Yonghua Zhan^#, Xu Cao^#, Yingchao Li, Xueli Chen*, and Xiaofeng Huang*, “Synthesis and biological evaluation of a novel apogossypolone derivative,” Letters in Drug Design & Discovery 2017, 14(1), 96-101. Apr. 2017DOI: 10.2174/1570180813666160722115855
28. Xueli Chen^#, Defu Yang^#, Fangfang Sun, Xu Cao, and Jimin Liang*, “Adaptively alternative light-transport-model-based three-dimensional optical imaging for longitudinal and quantitative monitoring of gastric cancer in live animal,” IEEE Transactions on Biomedical Engineering 2016, 63(10), 2095-2107. Oct. 1, 2016. DOI: 10.1109/TBME.2015.2510369
29. Yonghua Zhan^#, Xu Cao^#, Xin Cao, Fei Kang, Jing Wang, Jimin Liang, Zhimin Li*, and Xueli Chen*, “Simultaneous multimodality molecular imaging with neodymium-doped Y3Al3O12 nanoparticles,” Optoelectronics and Advanced Materials-Rapid Communications 2016, 10(9-10), 685-688. Sep.-Oct. 2016
30. Yunpeng Dai, Xueli Chen*, Jipeng Yin, Xiaoyu Kang, Guodong Wang, Xianghan Zhang, Yongzhan Nie, Kaichun Wu, and Jimin Liang*, “Investigation of injection dose and camera integration time on quantifying pharmacokinetics of a Cy5.5-GX1 probe with dynamic fluorescence imaging in vivo,” Journal of Biomedical Optics 2016, 21(8), 086001. DOI: 10.1117/1.JBO.21.8.086001 Sep. 2016
31. Yunpeng Dai, Jipeng Yin, Yu Huang, Xueli Chen*, Guodong Wang, Yajun Liu, Xianghan Zhang, Yongzhan Nie, Kaichun Wu, and Jimin Liang*, “In vivo quantifying molecular specificity of Cy5.5-labeled cyclic 9-mer peptide probe with dynamic fluorescence imaging,” Biomedical Optics Express 2016, 7(4), 1149-1159. DOI: 10.1364/BOE.7.001149 Apr. 2016
32. Xueli Chen*, Fangfang Sun, Defu Yang, and Jimin Liang, “Coupled third-order simplified spherical harmonics and diffusion equation-based fluorescence tomographic imaging of liver cancer,” Journal of Biomedical Optics 2015, 20(9), 090502. Sep. 21, 2015. DOI: 10.1117/1.JBO.20.9.090502
33. Xueli Chen*, Fangfang Sun, Defu Yang, Shenghan Ren, Qian Zhang, and Jimin Liang*, “Hybrid simplified spherical harmonics with diffusion equation for light propagation in tissues,” Physics in Medicine and Biology 2015, 60(16), 6305-6322. Aug. 3, 2015
34. Xin Cao^#, Xueli Chen^#, Fei Kang^#, Yonghua Zhan, Xu Cao, Jing Wang*, Jimin Liang*, and Jie Tian*, “Intensity enhanced Cerenkov luminescence imaging using terbium-doped Gd2O2S microparticles,”ACS Applied Materials & Interfaces 2015, 7(22), 11775-11782. Jun 10, 2015. DOI: 10.1021/acsami.5b00432.
35. Defu Yang, Xueli Chen*, Xu, Cao, Jing Wang, Jimin Liang, and Jie Tian, “Performance investigation of SP3 and diffusion approximation for three-dimensional whole-body optical imaging of small animals,” Medical & Biological Engineering & Computing 2015, 53(9), 805-814. DOI: 10.1007/s11517-015-1293-8 Sep. 2015
36. Xin Cao, Xueli Chen*, Fei Kang, Xu Cao, Yonghua Zhan, Jing Wang, Kaichun Wu, and Jimin Liang*, “Sensitivity improvement of Cerenkov luminescence endoscope with terbium doped Gd2O­2S nanoparticles,” Applied Physics Letters 2015, 106(21), 213702. DOI: 10.1063/1.4921858 May 2015
37. Hao Hu^#, Xin Cao^#, Fei Kang^#, Min Wang, Yenan Lin, Muhan Liu, Shujun Li, Liping Yao, Jie Liang, Jimin Liang, Yongzhan Nie, Xueli Chen*, Jing Wang*, Kaichun Wu*, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” European Radiology 2015, 25(6), 1814-1822. (2ndaffiliation) May 2015. DOI: 10.1007/s00330-014-3574-2
38. Xin Cao^#, Xueli Chen^#, Fei Kang^#, Yenan Lin, Muhan Liu, Hao Hu, Yongzhan Nie, Kaichun Wu, Jing Wang*, Jimin Liang*, and Jie Tian*, “Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies,” Biomedical Optics Express 2014, 5(10), 3660-3670. Oct. 1, 2014. DOI:10.1364/BOE.5.003660
39. Xueli Chen*, Defu Yang, Qitan Zhang, and Jimin Liang*, “L1/2 regularization based numerical method for effective reconstruction of bioluminescence tomography,” Journal of Applied Physics 2014, 115(18), 184702. May 14, 2014. DOI: 10.1063/1.4876675
40. Xueli Chen*, Qitan Zhang, Defu Yang, and Jimin Liang*, “Hybrid radiosity-SP3 equation based bioluminescence tomography reconstruction for turbid medium with low- and non-scattering regions,” Journal of Applied Physics 2014, 115(2), 024702. Jan 14, 2014. DOI: 10.1063/1.4862166
41. Defu Yang^#, Xueli Chen^#, Zhen Peng, Xiaorui Wang, Jorge Ripoll, Jing Wang, and Jimin Liang*, “Light transport in turbid media with non-scattering, low-scattering and high absorption heterogeneities based on hybrid simplified spherical harmonics with radiosity model,” Biomedical Optics Express 2013, 4(10), 2209-2223. Oct. 1, 2013
42. Xueli Chen*, Jimin Liang, Xin Cao, Defu Yang, Dongmei Chen, Jorge Ripoll, and Jie Tian*, “Feasibility study of endoscopic X-ray luminescence computed tomography: simulation demonstration and phantom application,” Journal of Applied Physics 2013, 114(8), 084701. Aug 28, 2013. DOI: 10.1063/1.4819299
43. Xueli Chen^#, Defu Yang^#, Xiaochao Qu, Hao Hu, Jimin Liang*, Xinbo Gao, and Jie Tian*, “Comparisons of hybrid radiosity-diffusion model and diffusion equation for bioluminescence tomography in cavity cancer detection,” Journal of Biomedical Optics 2012, 17(6), 066015. Jun. 5, 2012. DOI: 10.1117/1.JBO.17.6.066015
44. Zhenhua Hu^#, Xueli Chen^#, Jimin Liang*, Xiaochao Qu, Duofang Chen, Weidong Yang, Jing Wang, Feng Cao, and Jie Tian*, “Single photon emission computed tomography- guided Cerenkov luminescence tomography,” Journal of Applied Physics 2012, 112(2), 024703. Jul. 25, 2012. DOI: 10.1063/1.4739266
45. Qitan Zhang^#, Xueli Chen^#, Xiaochao Qu, Jimin Liang*, and Jie Tian*, “Comparative studies of lp-regularization-based reconstruction algorithms for bioluminescence tomography,” Biomedical Optics Express 2012, 3(11), 2816-2836. Nov. 1, 2012
46. Xueli Chen, Jimin Liang*, Xiaochao Qu, Yanbin Hou, Shouping Zhu, Duofang Chen, Xinbo Gao, and Jie Tian*, “Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging,” Journal of X-ray Science and Technology2012, 20(1), 31-44. Apr. 1, 2012. DOI 10.3233/XST-2012-0317
47. Xueli Chen, Jimin Liang*, Heng Zhao, Xiaochao Qu, Duofang Chen, Qitan Zhang, Xinbo Gao, and Jie Tain*, “Modeling and reconstruction of optical tomography for endoscopic applications: simulation demonstration,” Applied Physics Letters 2011, 99(7), 073702. Aug. 16, 2011. DOI:10.1063/1.3626033
48. Xueli Chen, Xinbo Gao*, Duofang Chen, Xiaopeng Ma, Xiaohui Zhao, Man Shen, Xiangsi Li, Xiaochao Qu, Jimin Liang, Jorge Ripoll, and Jie Tian*, “3D reconstruction of light flux distribution on arbitrary surfaces from 2D multi-photographic images,” Optics Express 2010, 18(19), 19876-19893. Sep. 13, 2010
49. Xueli Chen, Xinbo Gao*, Xiaochao Qu, Duofang Chen, Xiaopeng Ma, Jimin Liang, and Jie Tian, “Generalized free-space diffuse photon transport model based on the influence analysis of camera lens,” Applied Optics 2010, 49(29), 5654-5664. Oct. 7, 2010
50. Xueli Chen, Xinbo Gao*, Xiaochao Qu, Jimin Liang, Lin Wang, Da’an Yang, Anikitos Garofalakis, Jorge Ripoll, and Jie Tian*, “A study of photon propagation in free-space based on hybrid radiosity-radiance theorem,” Optics Express 2009, 17(18), 16266- 16280. Aug. 31, 2009