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个人简介

 

刘继欣

博士,副教授,博士生导师

社会任职:西安市儿童医院影像科客座教授

研究方向:基于医疗大数据和人工智能的医学图像计算及其应用

实验室地点:新校区G442

联系方式:liujixin@xidian.edu.cn; liujixin2010@gmail.com

 

 

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基于医疗大数据和人工智能的影像组学及其应用

    由于成像技术的迅速发展,医学影像已成为疾病管理中的重要模式,为临床提供了全名的视角和丰富的信息,在疾病筛查、早期诊断、治疗选择和预后评估等方面发挥着举足轻重的作用。现已知病灶形态或功能上的变化是由患者个体的基因、细胞、生理微环境、生活习惯和生存大环境等诸多因素共同决定的。若在常规影像学诊断基础上,采用自动或半自动分析方法将影像学数据转化为具有高分辨率的可挖掘的数据空间,深度挖掘数据,从医学图像中获取“疾病知识”,从而反映人体组织、细胞和基因水平的变化,将会对临床医学产生重大影响。

 

研究方向1:重大疾病神经行为、神经认知功能下降影像学预测平台

    借助现代磁共振成像技术手段,采集重大疾病患者大脑结构、功能图像,将信息科学中的新概念新技术引入数据分析中,借助人工智能的帮助融合患者临床病理诊断数据,建立重大疾病症状发展、神经行为、神经功能下降风险的影像学预测平台,并应用于临床诊疗评价中,为临床实现重大疾病发展的早期评估、预测提供客观、准确的影像学依据。

 

研究方向2:多模态医学图像计算平台的临床应用

    借助医学影像全面、无创、定量观测肿瘤整体形态,对肿瘤的发展过程和治疗反应随时监测。借助图像分割与重建,从放射影像中提取大量特征,通过深度挖掘数据、寻找疾病的内涵特征,为临床诊疗决策提供支持。

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研究生培养:

 

2017年国家奖学金(穆俊娅)

2017年度本科生“优秀毕业生”荣誉称号(王品一)

2017年度校优秀博士学位论文(南娇芬)

2015年度研究生“优秀毕业生”荣誉称号(闫雪梅)

2014年度“优秀研究生标兵”荣誉称号(闫雪梅)

2014年度研究生“优秀毕业生”荣誉称号(李国英)

2013年度研究生“优秀毕业生”荣誉称号(李静)

 

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团队获奖:

 

2016年度陕西省科学技术奖(二等奖)

2014年度中国体视学学会科学技术奖(一等奖) 

2014年度北京市科学技术奖(二等奖)

2012年度陕西省科学技术奖(二等奖)

2011年度陕西省高校科学技术奖(一等奖)

 

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承担项目:

 

主持国家自然科学基金面上项目:无先兆偏头痛患者针刺安慰剂疗效影像学预测研究(81871330),57万,2019/1-2022/12

主持国家自然科学基金面上项目:青少年偏头痛早期诊断与针刺疗效影像学研究(81471737),73万,2015/1-2018/12

主持国家自然科学基金青年项目:基于不同状态的针刺效应与安慰剂效应网络研究(81101108),23万,2012/1-2014/12

参与国家自然科学基金面上项目:原发性痛经患者疼痛发展个体差异影像学研究(81871331),19万,2019/1-2022/12

参与国家自然科学基金面上项目:基于多模态磁共振成像的功能性腹痛综合征脑网络机制研究(81371530),21万,2014/1-2017/12

参与国家自然科学基金面上项目:原发性痛经患者中枢结构功能、内分泌及子宫形态学交互模型研究(81571640),17.4万,2016/1-2019/12

参与河南省科技开放合作项目:基于核磁共振成像的人脑连接组计算系统构建(81571640),9万,2017/1-2019/12

参与国家自然科学基金面上项目:原络配穴协同调节偏头痛患者痛感受和痛情绪的脑基底节-皮层环路机制研究(81473603),12万,2015/1-2018/12

 

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发表论文:

 

 

2018

Tao Chen, Junya Mu, Qianwen Xue, Ling Yang, Wanghuan Dun, Ming Zhang(*), Jixin Liu(*). Whole brain structural MRI based classification of primary dysmenorrhea in pain-free phase: a machine learning study. Pain. 2018. Accepted

 

Jixin Liu, Junya Mu, Tao Chen, Ming Zhang, Jie Tian,White matter tract microstructure of the mPFC-amygdala predicts inter-individual differences in placebo response related to treatment in migraine patients,Human Brain Mapping,2018,Accepted

 

Junya Mu, Tao Chen, Peng Li, Dun Ding,Xueying Ma,Ming Zhang, Jixin Liu(*), Altered white matter microstructure mediates the relationship between hemoglobin levels and cognitive control deficits inend-stage renal disease patients. Human Brain Mapping. 2018. Accepted 

 

Peng Li, Dun Ding, Xueying Ma, Huangwen Zhang, Jixin Liu(*), Ming Zhang(*).Altered intrinsic brain activity and memory performance improvement in patients with end-stage renal disease during a single dialysis session. Brain Imaging & Behavior, 2018, doi: 10.1007/s11682-018-9828-x

 

Li A, Mu J, Huang M, & Jixin Liu(*), Ming Zhang(*). Altered amygdala-related structural covariance and resting-state functional connectivity in end-stage renal disease patients[J]. Metabolic Brain Disease, 2018:1-11.

 

Ma X, Zhang Y, Ma S, & Jixin Liu(*), Ming Zhang(*). Association between abnormal thalamic metabolites and sleep disturbance in patients with end-stage renal disease.[J]. Metabolic Brain Disease, 2018:1-8.

 

Junya Mu, & Jixin Liu(*), Ming Zhang(*). The variation of motor-related brain structure and its relation to abnormal motor behaviors in end-stage renal disease patients with restless legs syndrome. Brain Imaging & Behavior, 2018. Accepted

 

 

2017

Jixin Liu, Shaohui Ma, Junya Mu, Tao Chen,Qing Xu, Wanghuan Dun, Jie Tian, Ming Zhang,Integration of white matter network is associated with inter-individual differences in psychologically mediated placebo response in migraine patients,Human Brain Mapping,2017,38(10):5250-5259

 

Jixin Liu, Junya Mu, Qianqian Liu, Wanghuan Dun, Ming Zhang, Jie Tian,Brain structural properties predict psychologically mediated hypoalgesia in an 8-week sham acupuncture treatment for migraine,Human Brain Mapping,2017,38(9):4386-4397

 

Jixin Liu, Hongjuan Liu, Junya Mu, Qing Xu, Tao Chen, Wanghuan Dun,Jing Yang, Jie Tian, Li Hu, Ming Zhang,Altered white matter microarchitecture in the cingulum bundlein women with primary dysmenorrhea: a tract-based analysis study,Human Brain Mapping,2017;38(9):4430-4443

 

Mu J, Xu Q, Tian J(*), Jixin Liu(*). The effect of feature image on sensitivity of the statistical analysis in the pipeline of a tractography atlas-based analysis.[J]. Scientific Reports, 2017, 7(1).

 

Junya Mu, Tao Chen, Qianqian Liu, Dun Ding, Xueying Ma, Peng Li,Anmao Li, Mingxia Huang, Zengjun Zhang, Jixin Liu(*), Ming Zhang(*). Abnormal interaction between cognitive control network and affective network in patients with end-stage renal disease. Brain Imaging & Behavior, 2017(2):1-13.

 

Dun, Wang-Huan ,Yang, Jing,Yang, Ling,Ding, Dun,Ma, Xue-Ying,Liang, Feng-Li,von Deneen, Karen M,Ma, Shao-Hui,Xu, Xiao-Ling,Liu, Jixin (*),Zhang, Ming (*),Abnormal structure and functional connectivity of the anterior insula at pain-free periovulation is associated with perceived pain during menstruation.,Brain Imaging Behav,2017, 11(6):1787-1795

 

 

2016

Li, Kang ,Liu, Lijun,Yin, Qin,Dun, Wanghuan,Xu, Xiaolin,Liu, Jixin (*),Zhang, Ming (*),Abnormal rich club organization and impaired correlation between structural and functional connectivity in migraine sufferers,Brain Imaging Behav,2016.2.27

 

Nan, Jiaofen ,Zhang, Li,Zhu, Fubao,Tian, Xiaorui,Zheng, Qian,Deneen, Karen M von,Liu, Jixin (*),Zhang, Ming (*),Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia.,J Neurogastroenterol Motil,2016.1.31,22(1):118~128

 

 

2015

Liu, Jixin,Zhao, Ling,Lei Fangfei,Zhang Yi,Yuan Kai,Gong Q,Liang F,Tian(#) J,Disrupted resting-state functional connectivity and its changing trend in migraine suffers,Human Brain Mapping,2015,36(5):1892-907

 

Liu, Jixin,Lan Lei,Mu Junya,Zhao Ling,Yuan Kau,Zhang Yi,Huang L,Liang F,Tian J,Genetic contribution of catechol-O-methyltransferase in hippocampal structural and functional changes of female migraine sufferers,Human Brain Mapping,2015,36(5):1782-95

 

Nan, Jiaofen ,Liu, Jixin (*),Mu, Junya,Dun, Wanghuan,Zhang, Ming,Gong, Qiyong,Qin, Wei,Tian, Jie,Liang, Fanrong,Zeng, Fang,Brain-based borrelations between psychological factors and functional dyspepsia,Journal Neurogastroenterology Motility,2015.1.01,121(1):103~110

 

Nan, Jiaofen ,Liu, Jixin (*),et al., Anatomically related gray and white matter alterations in the brains of functional dyspepsia patients. Neurogastroenterology and Motility. 2015, 27(6):856-864

 

 

 

2014

Zhao, Ling, Liu, Jixin(*),Yan, Xuemei,Dun, Wanghuan,Yang,Huang, Liyu,Kai, Yuan,Yu, Dahua,Qin, Wei,Jie, Tian,Liang, Fanrong,Abnormal Brain Activity Changes in Patients with Migraine: A Short-Term Longitudinal Study,Journal of Clinical Neurology,2014.7.01,10(3):229~235

 

Nan, Jiaofen,Liu, Jixin(*),Zhang, D.,Yang, Yue,Yan, Xuemei,Yin, Qin,Xiong, Shiwei,Von Deneen, K. M.,Liang, Fanrong,Gong, Qiyong,Qin,Wei,Tian, Jie,Zeng, Fang,Altered intrinsic regional activity and corresponding brain pathways reflect the symptom severity of functional dyspepsia,Neuro-Gastroenterology and Motility,2014.5.01,26(5):660~669

 

Zhao, Ling, Liu, Jixin(*),Zhang, Fuwen,Dong, Xilin,Peng, Yulin,Qin, Wei,Wu, Fumei,Li, Ying,Yuan, Kai,von Deneen, Karen M.,Gong, Qiyong,Tang, Zili,Liang, Fanrong,Effects of Long-Term Acupuncture Treatment on Resting-State Brain Activity in Migraine Patients: A Randomized Controlled Trial on Active Acupoints and Inactive Acupoints,PLos One,2014.6.10,9(6)

 

 

2013

Liu, Jixin,Zhao, Ling,Nan, Jiaofen,Li, Guoying,Xiong,Shiwei,von Deneen, Karen M,Gong, Qiyong,Liang, Fanrong,Qin, Wei,Tian, Jie,The trade-off between wiring cost and network topology in white matter structural networks in health and migraine.,Experimental Neurology,2013.10.01,248:196~204

 

Liu, Jixin,Lan, Lei,Li, Guoying,Yan, Xuemei,Nan, Jiaofen,Xiong, Shiwei,Yin, Qing,von Deneen, Karen M,Gong, Qiyong,Liang, Fanrong,Qin, Wei,Tian, Jie,Migraine-Related Gray Matter and White Matter Changes at a 1-Year Follow-Up Evaluation.,Journal of Pain,2013.12.01,14(12):1703~1708

 

Liu, Jixin,Nan, Jiaofen,Xiong, Shiwei,Li, Guoying,Qin, Wei,Tian, Jie,Additional evidence for the sustained effect of acupuncture at the vision-related acupuncture point, GB37,Acupuncture in Medicine,2013.6.01,31(2):185~194

 

Zhao, Ling ,Liu, Jixin (Co-first author),Dong, Xilin,Peng, Yulin,Yuan, Kai,Wu, Fumei,Sun, Jinbo,Gong, Qiyong,Qin, Wei,Liang, Fanrong,Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration,Journal of Headache and Pain,2013.10.17,14:1~9

 

Nan, Jiaofen,Liu, Jixin (*),Li, Guoying,Xiong, Shiwei,Yan, Xuemei,Yin, Qing,Zeng, Fang,von Deneen, Karen M.,Liang, Fanrong,Gong, Qiyong,Qin, Wei,Tian, Jie,Whole-Brain Functional Connectivity Identification of Functional Dyspepsia,PLos One,2013.6.17,8(6):e65870

 

 

2012

Liu, Jixin,Zhao, Ling,Li, Guoying,Xiong, Shiwei,Nan, Jiaofen,Li, Jing,Yuan, Kai,von Deneen, Karen M.,Liang, Fanrong,Qin, Wei,Tian, Jie,Hierarchical Alteration of Brain Structural and Functional Networks in Female Migraine Sufferers,PLos One,2012.12.5,7(12):e51250

 

 

2011

Liu, Jixin,Qin, Wei,Guo, Qian,Sun, Jinbo,Yuan, Kai,Dong, Minghao,Liu, Peng,Zhang, Yi,von Deneen, Karen M.,Liu, Yijun,Tian, Jie ,Divergent Neural Processes Specific to the Acute and Sustained Phases of Verum and Sham Acupuncture,Journal of Magnetic Resonance Imaging,2011.1.01,33(1):33~40

 

Liu, Jixin,Qin, Wei,Nan, Jiaofen,Li, Jing,Yuan, Kai,Zhao, Ling,Zeng, Fang,Sun, Jinbo,Yu, Dahua,Dong, Minghao,Liu, Peng,von Deneen, Karen M.,Gong, Qiyong,Liang, Fanrong,Tian, Jie ,Gender-Related Differences in the Dysfunctional Resting Networks of Migraine Suffers,PLos One,2011.11.2,6(11):e27049

 

Liu, Jixin,Qin, Wei,Yuan, Kai,Li, Jing,Wang, Wei,Li, Qiang,Wang, Yarong,Sun, Jinbo,von Deneen, Karen M.,Liu, Yijun,Tian, Jie,Interaction between Dysfunctional Connectivity at Rest and Heroin Cues-Induced Brain Responses in Male Abstinent Heroin-Dependent Individuals,PLos One,2011.10.18,6(10):e23098

 

Jixin Liu, Wei Qin, Qian Guo, Jinbo Sun, Kai Yuan,, Peng Liu, Yi Zhang, Karen M. von Deneen, Yijun Liu, Jie Tian*. Distinct brain networks for time-varied characteristics of acupuncture. Neuroscience Letters, 353-358, 2010.

 Jixin Liu,Jimin Liang, Wei Qin, Jie Tian*, Kai Yuan,, Lijun Bai, Yi Zhang, Wei Wang, Yarong Wang, Qiang Li, Liyan Zhao, Lin Lu, Karen M. von Deneen, Yijun Liu, Mark S. Gold, Dysfunctional connectivity patterns in chronic heroin users: An fMRI study. Neuroscience Letters, 72-77, 2009

 

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